Laboratory of Neural Mechanisms of Decision-Making and Cognition
Institute of Neuroscience, Chinese Academy of Sciences
We are interested in the neural mechanisms underlying decision-making and high cognitive functions mostly using non-human primate animals. Using single unit electrophysiology techniques, we record and analyze neural activities in different brain areas when animals are making complex decisions. Ultimately, our research leads to the complete understanding of the neural basis of human intelligence.
1. Neural mechanism of probabilistic reasoning
Many decisions rely on fuzzy and inaccurate information, which can be quantified with probabilities mathematically. How the brain utilizes probability information during decision making has been one of the hot topics in the decision-making field. We train monkeys to perform probabilistic reasoning tasks in which they make decisions by viewing pictures that are probabilistically associated with rewards. By recording from multiple areas in the prefrontal and parietal cortices, we are piecing together the neural circuitry that learns, processes, and uses probabilistic information during decision making.
2. Neural computation of value information
Animals use value information to guide their decisions when evaluating options. How value information is acquired and represented in the brain is still not well understood. We train monkeys to recognize pictures that predict different rewards. We focus our investigation on the orbitofrontal cortex and study its role in representing different aspects of value information associated with visual stimuli, including reward magnitude, probability, and volatility. In addition to the animal model work, we also collaborate with local hospitals to study value-based decision-making behavior in humans, including both healthy subjects and patients suffering from a variety of mental disorders. These studies may provide us clues on how neural computation of value information is affected in these disorders and ultimately provide insights in developing new treatments.
3. Neural network modeling of the prefrontal cortex
The prefrontal cortex is critical for high cognitive brain functions. However, the neural computation it performs remains a mystery. One of the challenges is that our ability of recording from a large network of neurons is currently very limited. We are addressing this challenge by creating biologically-realistic neural network models based on experimental data to understand how neurons are wired together to achieve complex functions. By running simulations and studying network and neuron behavior, we use our models to not only explain experimental data collected from the real brain, but also provide testable ideas for future experimental investigations. Such study is essential for us to understand the neural computation principles underlying cognitive functions.