General

Ninglong Xu, Ph.D.

Principal Investigator

Institute of Neuroscience

Center for Excellence in Brain Science and Intelligence Technology

Chinese Academy of Sciences

320 Yueyang Road, Shanghai, 200031, P.R.China

Email: xunl@ion.ac.cn

Office Phone: +86-21-54921866

Lab website


Research Areas

  1. Systems neuroscience using behaving mice

  2. Neural circuits underlying auditory perception

  3. Neural circuits underlying perceptual decision making

  4. Cortical-basal ganglia circuits for action selection

  5. Two-photon imaging and optogenetics in behaving mice


Education

Ph.D.,  Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China, 2006

​B.S.,  Bioengineering, School of Life Sciences, Sichuan University, Chengdu, China 1999.  


Experience

• Principal Investigator and Lab Head, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai  (2013 ~ ). 

• Research Specialist, Howard Hughes Medical Ins$tute, Janelia Farm Research Campus  (2011 ~  2013).   

• Postdoctoral Associate, Howard Hughes Medical Ins$tute, Janelia Farm Research  Campus (2008 ~ 2011).  

• Postdoctoral Fellow, Cold Spring Harbor Laboratory (2006 ~ 2008)


Work Experience
   
Teaching Experience
   

Publications

1.   Wang Z, Xu NL, Wu CP, Duan S, and Poo MM, Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron, 37: 463-72  (2003).

 

2.   Xu NL, Ye CQ, Zhang XH, and Poo MM, Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction. J. Neurosci., 26: 3002-3009 (2006).

 

3.   Xu NL, Harnett MT, O’Connor DH, Huber D, Williams SR, Svoboda K., Magee JC, Nonlinear dendritic integration of sensory and motor input during an active sensing task. Nature, 492: 247-251 (2012).

 

4.   Petreanu L, Gutnisky DA, Huber D, Xu NL, O’Connor DH, Tian L, Looger L, and Svoboda K, Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature, 489: 299–303 (2012).

 

5.   Harnett MT, Xu NL, Magee JC, Williams SR, Potassium Channels Control the Interaction between Active Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons. Neuron, 79: 516-529 (2013).

 

6.   Chen JL, Andermann ML, Keck T, Xu NL, and Ziv Y, Imaging Neuronal Populations in Behaving Rodents: Paradigms for Studying Neural Circuits Underlying Behavior in the Mammalian Cortex. J. Neurosci., 33(45): 17631-17640 (2013).

 

7.   Guo ZV, Hires SA, Li N, O'Connor DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S, Xu NL, Cox J, Svoboda K, Procedures for Behavioral Experiments in Head-Fixed Mice. PLoS ONE 9, e88678 (2014).


Papers
   
Patents
   

Research Interests

      The goal of our research is to understand how the architectures and functional operations of neuronal circuits mediate percept formation and perceptual decision in the mammalian brain. We combine inovative recording and manipulation methods including in vivo two-photon imaging, optogenetics and highly controlled mouse behavioral system to address the following basic questions: 
  1. How does the interaction between higher order cortex and sensory cortex support percept formation? We focus on the impact of long-distance top-down projections on local circuit computation in the sensory cortex. 
  2. How is perception linked to decision to guide behavior in a flexible and adaptive way? We focus on association cortices including posterior parietal cortex and prefrontal cortex and their interaction with other cortical and subcortical regions during perceptual decision. 
  3. How does the brain select motor plans? We focus on the higher motor cortices and its interaction with subcortical regions including the basal ganglia, superior colliculus and thalamus. 

       

Answers to these questions will ultimately help understanding the fundamental neural mechanisms governing our conscious perception. 


Conferences

   

Collaboration

   

Students

现指导学生

唐顺航  02  19179  

辛宇  01  19179  

崔乐乐  01  19179  

柴睿明  01  19179  

钟林  01  19179  

张园  01  19179  

刘彦和  01  19179  

Honors & Distinctions